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Can I take 50 and Fish oil together?

Drug interaction guide

Taking 50mg of sertraline with fish oil may slightly increase your risk of bruising or bleeding. While both are generally safe to take together, they both have mild blood-thinning effects which can add up when combined.

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Why this happens

Sertraline (an SSRI) can affect how platelets in your blood clump together to stop bleeding. Fish oil (omega-3 fatty acids) also has a mild natural blood-thinning effect. Together, they may make your blood take slightly longer to clot.

It is usually fine to take these together, but you should use caution. Watch for signs of unusual bruising, nosebleeds, or gums that bleed more than usual when brushing your teeth. If you are planning to have surgery, tell your doctor or surgeon that you are taking both of these supplements.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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