Can I take Agomelatine and Esomeprazole together?

Why this happens

Agomelatine is broken down in the liver primarily by an enzyme called CYP1A2. Esomeprazole can slightly interfere with (inhibit) this enzyme, which means the body processes agomelatine more slowly than usual.

This interaction is generally considered minor, and most people can take both safely. However, you should monitor yourself for any increased side effects. If you feel unusually drowsy or dizzy, speak to your doctor. It is also important to avoid smoking while taking agomelatine, as smoking has a much larger effect on this medication than esomeprazole does.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.