Can I take Agomelatine and Metoclopramide together?

Why this happens

Agomelatine is primarily broken down by a specific liver enzyme (CYP1A2), while metoclopramide is processed by a different pathway (CYP2D6). Because they use different 'routes' through the liver, they do not interfere with each other's levels in the blood. Additionally, agomelatine works on melatonin and serotonin receptors to treat depression, while metoclopramide works on dopamine receptors to treat nausea; these actions do not overlap in a way that causes harm.

You can take these two medicines together. However, as with any new medication, monitor how you feel. If you experience unusual drowsiness or feel particularly unwell, speak to your doctor or pharmacist. Always ensure your doctor knows all the medications you are taking.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.