git add

Skip to main content

Can I take Allergy and Allopurinol together?

Drug interaction guide

Taking allopurinol if you have a history of severe allergies or certain skin conditions can significantly increase your risk of a life-threatening allergic reaction.

Video picks for Drug interactions

Continue reading below

Why this happens

Allopurinol can trigger a severe immune system overreaction in sensitive individuals. This is more common in people who have previously had severe drug allergies or carry specific genetic markers.

Before starting allopurinol, tell your doctor about all your allergies. If you develop any skin rash, mouth sores, or fever while taking this medicine, stop taking it immediately and seek urgent medical attention.

Continue reading below

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Continue reading below

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
flu eligibility checker

Ask, share, connect.

Browse discussions, ask questions, and share experiences across hundreds of health topics.

symptom checker

Feeling unwell?

Assess your symptoms online for free

Sign up to the Patient newsletter

Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.

Please enter a valid email address

By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.