Can I take Allopurinol and Mirtazapine together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There are no known significant interactions between allopurinol and mirtazapine. It is generally considered safe to take these two medications together.
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Why this happens
Allopurinol and mirtazapine are processed by different pathways in the body. Allopurinol works by blocking an enzyme called xanthine oxidase to lower uric acid levels, while mirtazapine affects chemical messengers in the brain. They do not interfere with each other's absorption, metabolism, or excretion.
What you should do
Back to contentsYou can take both medications as prescribed by your doctor. However, as with any combination of medicines, you should monitor for any new or unusual side effects and inform your healthcare provider if you feel unwell.
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Important precautions
Back to contentsSevere skin reactions (SCARs)
Stop taking allopurinol immediately and seek urgent medical help if you develop a skin rash, peeling skin, or mouth ulcers. This can be a sign of a rare but life-threatening allergic reaction.
Agranulocytosis (low white blood cells)
Contact your doctor immediately if you develop signs of infection, such as a high temperature, sore throat, or mouth ulcers. Mirtazapine can rarely cause a serious drop in white blood cells.
Food and drink warnings
Back to contentsAlcohol
Alcohol can increase the sedative effects of mirtazapine, making you feel much sleepier and less alert. It is best to avoid drinking alcohol while taking this medicine, especially when you first start treatment or if your dose is increased.
Water/Hydration
It is important to drink plenty of fluids (at least 2 to 3 litres a day) while taking allopurinol. This helps to prevent the formation of kidney stones and ensures the medicine works correctly.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking these two medicines together significantly increases the risk of a rare but serious condition called 'serotonin syndrome'. This happens when there is too much of a chemical called serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle twitching, or diarrhoea. In severe cases, it can be life-threatening.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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