Can I take Amatriptyline and Elvanse adult together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Taking amitriptyline and Elvanse Adult (lisdexamfetamine) together can increase the risk of serious side effects, including high blood pressure, a fast or irregular heartbeat, and a rare but serious condition called serotonin syndrome. It can also increase the risk of seizures.
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Why this happens
Both medications increase the levels of certain chemicals in the brain and body, such as norepinephrine (noradrenaline) and serotonin. When used together, these effects can add up, leading to excessive stimulation of the heart and nervous system. Amitriptyline can also slow down the breakdown of Elvanse in the body, making its effects stronger and longer-lasting.
What you should do
Back to contentsYou must speak to your doctor before taking these two medicines together. If your doctor decides this combination is necessary, they will likely monitor your heart rate and blood pressure closely. Seek immediate medical help if you experience a very fast heartbeat, chest pain, severe headache, confusion, muscle twitching, or high fever.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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