Can I take Amitriptyline and Dapagliflozin together?

Why this happens

Amitriptyline can sometimes cause a drop in blood pressure when you stand up (orthostatic hypotension). Dapagliflozin works by removing sugar and extra fluid through your urine, which can also lower blood pressure or cause mild dehydration. Together, these effects can add up. Additionally, while dapagliflozin lowers blood sugar, amitriptyline can occasionally affect how the body handles glucose, though this is less common.

You can usually take these medicines together, but you should be careful when rising from a sitting or lying position. Drink plenty of water to stay hydrated. If you feel very dizzy, faint, or notice significant changes in your blood sugar readings, speak to your doctor or pharmacist.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.