Can I take Amlodipine and Epipen adrenaline together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Amlodipine may reduce the effectiveness of an EpiPen (adrenaline) during a severe allergic reaction. Additionally, the combination can cause unpredictable changes in blood pressure and heart rate.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Amlodipine works by relaxing blood vessels to lower blood pressure. Adrenaline (EpiPen) works by narrowing blood vessels and increasing heart rate to treat life-threatening allergic reactions (anaphylaxis). Because they have opposite effects on the blood vessels, amlodipine can make it harder for the adrenaline to work effectively. Furthermore, amlodipine can sometimes cause the heart to beat faster in response to adrenaline, or conversely, prevent the blood pressure from rising as much as needed during an emergency.
What you should do
Back to contentsIf you are experiencing a severe allergic reaction, use your EpiPen as instructed and seek emergency medical help immediately (call 999). Tell the emergency medical staff that you take amlodipine. You do not need to stop taking your daily amlodipine, but you must ensure your doctor is aware you have been prescribed an EpiPen, as they may wish to review your blood pressure medication.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Drug interactions checker
Can I take Lisinopril and Potassium together?
Taking lisinopril and potassium supplements together can cause the levels of potassium in your blood to become dangerously high (a condition called hyperkalaemia). While your body needs potassium for your heart and muscles to work, too much of it can lead to serious heart rhythm problems or even cause the heart to stop. Symptoms of high potassium can include muscle weakness, tingling sensations, or palpitations, but often there are no symptoms until the level is very high.
Drug interactions checker
Can I take Sertraline and Fluoxetine together?
Taking sertraline and fluoxetine together significantly increases the risk of a rare but serious condition called serotonin syndrome. This happens because both medicines work by increasing the level of a chemical called serotonin in your brain. If levels get too high, it can cause symptoms like shivering, diarrhoea, confusion, severe muscle tightness, fever, and even seizures. Additionally, fluoxetine can slow down how your body breaks down sertraline, leading to a build-up of the drug in your system and increasing the risk of side effects.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.