Can I take Amlodipine and Fluoxetine together?

Why this happens

Fluoxetine can slow down the liver enzymes (specifically one called CYP3A4) that your body uses to break down amlodipine. This means amlodipine stays in your system longer. Additionally, both drugs can lower blood pressure, leading to a combined effect.

You can usually take these together, but you should monitor your blood pressure regularly at home. If you feel dizzy, lightheaded (especially when standing up), or notice increased swelling in your legs, speak to your doctor. They may need to adjust your amlodipine dose.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.