Can I take Anastrozole and Omeprazole together?

Why this happens

Anastrozole does not require a specific stomach acid level to be absorbed properly, so the acid-reducing effects of omeprazole do not interfere with it. Furthermore, these drugs are processed by different pathways in the liver, meaning they do not compete with or affect each other's metabolism.

You can continue to take both medications as prescribed by your doctor. You do not need to space them apart or change the time of day you take them. Always inform your healthcare team if you start any new supplements or over-the-counter medicines.

Pregnancy and Breastfeeding

You must not take anastrozole if you are pregnant or breastfeeding, as it can cause serious harm to the developing baby. It is only for use in women who have reached menopause.

Osteoporosis (Bone thinning)

Anastrozole lowers oestrogen levels, which can significantly reduce bone mineral density and increase your risk of fractures. Your doctor should monitor your bone health before and during treatment.

Vitamin B12 Deficiency

Long-term use of omeprazole (usually more than 3 years) can prevent your body from absorbing Vitamin B12 properly, potentially leading to a deficiency.

Alcohol

While alcohol does not directly interact with omeprazole, it can increase stomach acid production and irritate the stomach lining, which may worsen the symptoms you are taking omeprazole to treat. It is best to limit alcohol intake.

Caffeine (Coffee, Tea, Energy Drinks)

Caffeine can trigger or worsen symptoms of acid reflux and indigestion. If you are taking omeprazole for these conditions, you may find that reducing caffeine helps the medicine work more effectively.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.