Can I take Ashwagandha and Glucosamine together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known significant interactions between ashwagandha and glucosamine. Both are generally considered safe to take together for most people.
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Why this happens
Ashwagandha is an adaptogenic herb that primarily affects the body's stress response (cortisol levels), while glucosamine is an amino sugar used by the body to build cartilage. They are processed by different pathways in the body and do not interfere with how the other is absorbed, broken down, or used.
What you should do
Back to contentsYou can safely take these two supplements together. However, as with any supplement, you should monitor for any unusual side effects. If you have diabetes, be aware that glucosamine can occasionally affect blood sugar levels, and ashwagandha may lower blood sugar; monitor your levels closely if you have this condition.
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Important precautions
Back to contentsHyperthyroidism (overactive thyroid)
Ashwagandha can increase thyroid hormone levels, which may worsen hyperthyroidism or interfere with thyroid medications.
Autoimmune diseases (e.g. Lupus, Rheumatoid Arthritis, Multiple Sclerosis)
Ashwagandha can stimulate the immune system, which may worsen symptoms of autoimmune conditions or reduce the effectiveness of immunosuppressant drugs.
Shellfish allergy
Many glucosamine supplements are derived from the shells of crustaceans; patients with a shellfish allergy must check the source to avoid a potentially severe allergic reaction.
Food and drink warnings
Back to contentsAlcohol
Ashwagandha may have sedative effects. Combining it with alcohol can increase drowsiness, sleepiness, and impaired coordination. It is best to avoid or strictly limit alcohol while taking this supplement.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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