Can I take Aspirin and Nexium together?

Why this happens

Aspirin is known to irritate the stomach lining and increase the risk of ulcers. Nexium is a proton pump inhibitor (PPI) that reduces stomach acid, which provides a protective effect against this damage. From a chemical standpoint, Nexium raises the pH level in the stomach; this can cause enteric-coated aspirin to dissolve earlier than intended (in the stomach rather than the intestine), which might slightly alter its effectiveness or cause minor stomach upset.

It is generally safe and very common to take these two medicines together. In fact, doctors often prescribe Nexium specifically to protect the stomachs of patients who need to take aspirin daily. You do not usually need to change how you take them, but if you notice any new stomach pain or indigestion, mention it to your pharmacist or doctor.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.