Can I take Aspirin and Octasa together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Taking aspirin and Octasa (mesalazine) together can increase the risk of side effects, particularly damage to the kidneys and an increased risk of stomach ulcers or bleeding. It may also increase the risk of blood disorders.
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Why this happens
Both aspirin and Octasa belong to the same chemical family (salicylates). Because they work in similar ways, taking them together creates an 'additive effect'. This means the levels of salicylate in your body become higher, putting extra strain on your kidneys and the lining of your stomach. Additionally, Octasa can sometimes interfere with how the body produces blood cells, and aspirin can worsen this effect.
What you should do
Back to contentsYou should consult your doctor before taking these two medicines together. Your doctor may want to monitor your kidney function with regular blood tests or may suggest an alternative painkiller, such as paracetamol, which does not interact with Octasa. If you are prescribed low-dose aspirin for heart protection, do not stop taking it, but ensure your specialist is aware you are also taking Octasa.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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