Can I take Aspirin and Quetiapine together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking aspirin and quetiapine together may increase your risk of bleeding, particularly in the stomach or gut. It can also increase the risk of feeling dizzy or faint when you stand up.
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Why this happens
Aspirin thins the blood and can irritate the stomach lining, while quetiapine can sometimes interfere with how platelets (the cells that help blood clot) work. Additionally, both medications can cause a drop in blood pressure when standing, which may lead to dizziness.
What you should do
Back to contentsYou should use this combination with caution. Watch for signs of unusual bleeding, such as easy bruising, dark or 'tarry' stools, or coughing up blood. To avoid dizziness, try to stand up slowly from a sitting or lying position. If you have a history of stomach ulcers, speak to your doctor before taking aspirin.
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Important precautions
Back to contentsAsthma
Do not take aspirin if you have a history of asthma triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can cause a life-threatening asthma attack.
Children and teenagers under 16
Never give aspirin to children or teenagers under 16 unless specifically prescribed by a doctor, due to the risk of Reye’s syndrome, a rare but fatal condition affecting the brain and liver.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking aspirin increases the risk of developing stomach irritation, ulcers, and bleeding in the digestive tract. It is best to limit or avoid alcohol.
Grapefruit juice
Grapefruit and grapefruit juice can increase the amount of quetiapine in your blood, which may lead to more side effects. You should avoid consuming grapefruit products while taking this medicine.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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