Can I take Azathioprine and Evacal together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Evacal (calcium carbonate and vitamin D3) can interfere with how your body absorbs azathioprine if they are taken at the same time. This could make the azathioprine less effective at treating your condition.
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Why this happens
Calcium carbonate acts as an antacid. It can change the acidity levels in your stomach or physically bind to the azathioprine, which prevents the medicine from being fully absorbed into your bloodstream.
What you should do
Back to contentsYou should separate the doses of these two medicines. It is generally recommended to take azathioprine at least 2 hours before or 4 to 6 hours after taking your Evacal supplement. Speak to your pharmacist to help you create a dosing schedule that works for you.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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