Can I take Black cohosh and Glucosamine together?
Drug interaction guide
Originally published 25 Jan 2026
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There is no known significant interaction between black cohosh and glucosamine. Both are generally considered safe to take together for most people.
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Why this happens
These two substances are processed by the body through different pathways. Glucosamine is an amino sugar used by the body to build cartilage, while black cohosh is a herbal remedy that primarily affects hormonal pathways or neurotransmitters. They do not compete for the same enzymes in the liver (such as the Cytochrome P450 system) to a degree that would cause a dangerous buildup of either substance.
What you should do
Back to contentsYou can take these two supplements together. However, as with any supplement regime, you should monitor how you feel. If you have liver problems, consult your doctor before taking black cohosh, as it has been linked to rare cases of liver inflammation. If you have a shellfish allergy, ensure your glucosamine is from a vegan or bovine source.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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