Can I take Bupropion and Magnesium together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
There is a potential increased risk of seizures when taking bupropion and magnesium together, particularly if magnesium levels in the blood become too high or too low. Additionally, some forms of magnesium may interfere with how bupropion is absorbed.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Bupropion is known to lower the 'seizure threshold', making seizures more likely. Magnesium plays a critical role in nerve and muscle function; significant imbalances in magnesium levels can also trigger seizures. Furthermore, magnesium supplements can sometimes alter the acidity of the stomach or bind to other medications, potentially changing how much bupropion enters the bloodstream.
What you should do
Back to contentsConsult your doctor or pharmacist before combining these. If you are prescribed magnesium for a deficiency, it is important to take it, but your doctor should monitor your levels closely. If you are taking magnesium as an over-the-counter supplement or antacid, space the doses at least 2 hours apart from your bupropion. Seek immediate medical help if you experience a seizure, severe dizziness, or confusion.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Pregabalin and Prozac together?
Taking pregabalin and Prozac (fluoxetine) together can increase the risk of side effects that affect your brain and nervous system. You may feel more drowsy, dizzy, or confused. It can also make it harder to concentrate or perform tasks that require alertness. In some cases, especially in older adults, it may lead to impaired thinking or coordination. There is also a small but serious risk of a rare condition called serotonin syndrome, which can cause shivering, sweating, and a fast heartbeat.

Drug interactions checker
Can I take Colecalciferol and Tizanidine together?
There are no known significant interactions between colecalciferol and tizanidine. It is generally considered safe to take these two medications together.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.