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Can I take Buscopan and Lansoprazole together?

Drug interaction guide

There is no known direct interaction between Buscopan (hyoscine butylbromide) and lansoprazole. It is generally considered safe to take these two medicines together.

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Why this happens

Lansoprazole works by reducing the amount of acid produced in the stomach. Buscopan works by relaxing the muscles in the digestive system to relieve cramps. They work in different ways and do not interfere with how the body absorbs or processes each other.

You can take both medicines as prescribed or directed on the packaging. However, if you are taking Buscopan for stomach pain and it does not improve within 48 hours, or if you have new symptoms like unintended weight loss or blood in your stools, you should speak to your doctor.

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Glaucoma

Do not take this medicine if you have glaucoma (increased pressure in the eye), as it can cause a sudden, painful increase in eye pressure and potentially damage your vision.

Severe diarrhoea

If you develop severe or persistent watery diarrhoea, contact your doctor immediately. This medicine can increase the risk of a serious bacterial bowel infection called C. difficile.

Food (General)

Lansoprazole works best when taken on an empty stomach, at least 30 minutes before food. Taking it with food can make it less effective at reducing stomach acid.

Alcohol

While there is no direct interaction, both Buscopan and alcohol can cause drowsiness or dizziness. Drinking alcohol while taking this medicine may increase these side effects.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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