Can I take Calcichew-d3 and Levothyroxine together?
Drug interaction guide
Originally published 12 May 2026
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Taking Calcichew-D3 at the same time as levothyroxine can significantly reduce the amount of thyroid hormone your body absorbs. This can lead to your thyroid medication not working properly, potentially causing symptoms of an underactive thyroid such as tiredness, weight gain, and feeling cold.
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Why this happens
The calcium carbonate in Calcichew-D3 binds to the levothyroxine in your stomach and intestines. This creates a complex that is too large for your body to absorb into the bloodstream, meaning the medicine simply passes through your system without effect.
What you should do
Back to contentsYou must separate the doses of these two medications. It is recommended to take your levothyroxine on an empty stomach first thing in the morning, and then wait at least 4 hours before taking your Calcichew-D3. Do not stop taking either medication without consulting your doctor, as they may need to monitor your thyroid levels.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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