Can I take Calcium and Sertraline together?

Why this happens

Calcium does not interfere with how the body absorbs, breaks down, or uses sertraline. Similarly, sertraline does not affect calcium levels or its absorption.

You can take these two together. You do not need to space them apart or change your routine. However, always inform your doctor or pharmacist about all supplements you are taking.

Drug-drug interaction (Absorption)

Calcium supplements can prevent sertraline from being absorbed properly. You must space these medicines at least 2 hours apart.

Bleeding risk

Sertraline increases your risk of internal bleeding, especially if you take aspirin, ibuprofen, or blood thinners like warfarin. Seek medical help for unusual bruising or black stools.

Low sodium (Hyponatraemia)

Sertraline can cause a dangerous drop in blood sodium levels, particularly in older patients. Contact your doctor if you experience unexplained confusion, muscle weakness, or seizures.

Alcohol

It is best to avoid drinking alcohol while taking sertraline. Alcohol can increase the risk of side effects like drowsiness, dizziness, and impaired coordination.

Grapefruit juice

Grapefruit juice can increase the levels of sertraline in your blood, which may increase the risk of side effects. It is generally advised to avoid or limit grapefruit juice while taking this medicine.

Caffeine (Coffee, Tea, Energy drinks)

Caffeine can slightly reduce how much calcium your body absorbs. If you consume a lot of caffeine, try to take your calcium supplement at a different time of day.

High-fibre foods (e.g., whole grains, bran) and Spinach/Rhubarb

Foods very high in fibre or containing oxalates (like spinach and rhubarb) can interfere with calcium absorption. Try to take your calcium supplement at least 2 hours before or after eating these foods.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.