Can I take Dapagliflozin and Ibuprofen together?

Why this happens

Dapagliflozin works by making the kidneys filter sugar out of the blood, which also causes more water to leave the body. Ibuprofen (an NSAID) reduces the blood flow into the kidneys. When these two effects happen at the same time, the kidneys can become 'stressed' and struggle to function properly, especially if you are dehydrated.

You should avoid taking ibuprofen regularly while taking dapagliflozin. If you need pain relief, paracetamol is generally a safer choice. If you must take ibuprofen, keep it to the lowest dose for the shortest time possible, and ensure you drink plenty of water. Contact your doctor immediately if you notice a decrease in how much you urinate, swelling in your ankles, or unusual tiredness.

Asthma

Do not take this medicine if you have asthma, as it can cause a life-threatening worsening of your breathing or a severe allergic reaction.

Diabetic Ketoacidosis (DKA) risk

Seek urgent medical help if you feel very unwell with nausea, stomach pain, or fruity-smelling breath. This medicine can cause a serious condition called ketoacidosis, even if your blood sugar levels appear normal.

Dehydration and Kidney Function

Taking these together significantly increases the risk of acute kidney injury. You must stay well-hydrated and stop taking them temporarily if you have a fever, diarrhoea, or vomiting.

Alcohol

Drinking alcohol with dapagliflozin can increase the risk of dehydration and a serious condition called diabetic ketoacidosis (DKA). When taking ibuprofen, alcohol can increase the risk of stomach irritation and bleeding. It is best to limit or avoid alcohol while taking these medicines.

Water and non-alcoholic fluids

Dapagliflozin works by removing sugar through your urine, which can cause dehydration. It is important to drink plenty of water and non-alcoholic fluids throughout the day to stay hydrated.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.