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Can I take Dapagliflozin and Metformin together?

Drug interaction guide

Taking these two medicines together is generally safe and very common for managing type 2 diabetes. However, because both drugs work to lower your blood sugar, there is a slightly higher risk of your blood sugar dropping too low (hypoglycaemia), although this is still uncommon unless you also take other diabetes medications like insulin or sulphonylureas. There is also a rare but serious risk of a condition called ketoacidosis, where the blood becomes too acidic.

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Why this happens

Dapagliflozin works by helping your kidneys remove excess sugar through your urine. Metformin works by reducing the amount of sugar your liver produces and helping your body respond better to its own insulin. Because they lower blood sugar in different ways, their effects are additive (they work together to provide better control than either drug alone).

You should continue taking your medication as prescribed. Learn to recognise the signs of low blood sugar (such as feeling shaky, sweaty, or dizzy) and keep a source of quick-acting sugar nearby. It is important to stay well-hydrated and seek medical advice immediately if you feel very unwell, have nausea, vomiting, or stomach pain, as these can be signs of ketoacidosis. Always tell your doctor if you are scheduled for surgery or have a severe illness, as you may need to temporarily stop taking dapagliflozin.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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