Can I take Diltiazem and Losartan together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Taking diltiazem and losartan together can cause your blood pressure to drop lower than intended. This might make you feel dizzy, lightheaded, or faint, especially when standing up quickly. In some cases, diltiazem may also slightly increase the levels of losartan in your blood.
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Why this happens
Both medicines are used to treat high blood pressure but work in different ways. Diltiazem is a calcium channel blocker and losartan is an angiotensin II receptor blocker. When used together, their effects add up (an additive effect). Additionally, diltiazem can slow down the enzymes in the liver that break down certain medicines, which may slightly change how losartan is processed.
What you should do
Back to contentsIt is common for doctors to prescribe these together, but you should monitor your blood pressure regularly at home. Be careful when getting out of bed or standing up. If you feel very dizzy, experience a racing heartbeat, or feel like you might faint, contact your doctor. They may need to adjust your doses.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published

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