Can I take Duloxetine and Letrozole together?

Why this happens

Duloxetine is a mild inhibitor of an enzyme in the liver called CYP2D6. While letrozole is mainly broken down by other enzymes, a small part of its metabolism involves pathways that duloxetine can interfere with, potentially leading to a slight rise in letrozole levels.

You can usually take these two medicines together. However, you should monitor for any increase in letrozole side effects, such as joint pain, hot flushes, or extreme tiredness. If you notice these symptoms becoming worse, mention it to your doctor at your next appointment.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.