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Can I take Forxiga and Trazadone together?

Drug interaction guide

Taking Forxiga (dapagliflozin) and trazodone together may increase the risk of your blood pressure dropping too low, especially when you stand up. This can make you feel dizzy, lightheaded, or faint. Additionally, both medications can occasionally affect blood sugar levels, though in different ways.

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Why this happens

Forxiga is a SGLT2 inhibitor that works by removing sugar and water from the body through urine, which can naturally lower blood pressure. Trazodone is an antidepressant that can cause 'orthostatic hypotension' (a sudden drop in blood pressure when changing positions) as a side effect. When used together, these effects can add up. While Forxiga lowers blood sugar, trazodone can rarely interfere with blood sugar control in some patients.

You can usually take these together, but you should be cautious. Move slowly when rising from a sitting or lying position to avoid dizziness. Ensure you drink plenty of water to stay hydrated. If you have diabetes, monitor your blood sugar levels regularly. If you feel severely dizzy, faint, or notice unusual changes in your blood sugar, contact your doctor or pharmacist.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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