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Can I take Furosemide and Rosuvastatin together?

Drug interaction guide

There is a potential risk of muscle-related side effects when taking these two medicines together. While not common, the combination may increase the chance of developing muscle pain, tenderness, or weakness. In very rare cases, this can lead to a serious condition called rhabdomyolysis, where muscle tissue breaks down and can cause kidney damage.

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Why this happens

Both furosemide and rosuvastatin can independently affect the muscles. Furosemide can cause changes in your body's salt and fluid levels (electrolytes), which can make muscles more vulnerable. Additionally, some studies suggest that furosemide might slightly increase the levels of rosuvastatin in your blood by competing for the same transport proteins in the body, though this effect is usually mild.

You can usually take these medicines together, but you should be vigilant. Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or feel generally unwell. Your doctor may want to monitor your kidney function and salt levels (via blood tests) more closely.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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