Can I take Iron and Sertraline together?

Why this happens

Sertraline (an SSRI antidepressant) and iron (a mineral) are processed by the body through different pathways. Sertraline is broken down by the liver, while iron is absorbed in the gut and managed by blood proteins. They do not compete for absorption or metabolism.

You can take these medications together. However, iron supplements can sometimes cause stomach upset or constipation, which are also potential side effects of sertraline. If you experience these issues, try taking your iron with food (unless your doctor has told you otherwise) or at a different time of day than your sertraline to help your stomach settle.

Accidental overdose in children

Iron supplements are a leading cause of fatal poisoning in children. You must store them in a secure place out of the reach and sight of children.

Bleeding risk

Sertraline increases your risk of bleeding. You must seek medical advice before taking it with anti-inflammatory painkillers (like ibuprofen or aspirin) or blood-thinning medications.

Interaction with other medicines

Iron can stop other medicines from working. You must leave a gap of at least 2 hours between taking iron and other medications, particularly antibiotics or thyroid hormones.

Tea and Coffee (Caffeine)

Tea and coffee contain compounds called tannins and polyphenols that significantly reduce the amount of iron your body absorbs. Avoid drinking tea or coffee for at least one hour before or two hours after taking your iron supplement.

Dairy products (Milk, Cheese, Yoghurt)

Calcium in dairy products prevents the absorption of iron. Do not take your iron supplement at the same time as dairy products. Leave a gap of at least two hours between them.

Eggs and Whole-grain cereals

These foods contain phytates or proteins that can bind to iron and stop it from being absorbed properly. It is best to take iron on an empty stomach, though you can eat a small amount of food (avoiding dairy/tea) if it upsets your stomach.

Alcohol

You should avoid drinking alcohol while taking sertraline. Alcohol can increase the sedative effects of the medication, making you feel more drowsy, dizzy, or uncoordinated.

Grapefruit juice

Grapefruit juice can increase the levels of sertraline in your blood, which may increase the risk of side effects. It is best to avoid grapefruit juice while taking this medicine.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.