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Can I take Lenzetto spray and Levothyroxine together?

Drug interaction guide

Taking Lenzetto (estradiol) may reduce the effectiveness of your levothyroxine. This means your thyroid hormone levels could drop, potentially leading to symptoms of an underactive thyroid (hypothyroidism), such as tiredness, feeling cold, or weight gain.

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Why this happens

Lenzetto contains oestrogen. Oestrogen increases the amount of a specific protein in your blood (thyroxine-binding globulin) that 'mops up' thyroid hormone. When more of this protein is present, there is less active thyroid hormone available for your body to use.

You do not need to stop either medication, but you should inform your doctor that you are using both. Your doctor will likely need to perform a blood test (TSH test) about 6 to 12 weeks after starting Lenzetto to see if your levothyroxine dose needs to be increased. If you already take both and feel unusually tired or sluggish, book a review with your GP.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 12 May 2026 | Originally published
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