Can I take Lions mane and Turkey tail together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known negative interactions between Lion's Mane (Hericium erinaceus) and Turkey Tail (Trametes versicolor). In fact, these two medicinal mushrooms are frequently taken together in 'mushroom blends' because they work in different ways to support the body.
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It is generally considered safe to take Lions Mane and Turkey Tail together as they target different systems and are not known to interfere with the liver enzymes that break down supplements.
Lion's Mane primarily contains compounds called hericenones and erinacines which focus on brain health and nerve growth. Turkey Tail is rich in polysaccharopeptides (PSK and PSP) which focus on supporting the immune system.
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How to take Lions Mane and Turkey Tail together
Always start with a low dose to ensure you do not have an individual sensitivity or digestive upset.
If you are taking blood-thinning medication or have an upcoming surgery, consult your doctor first, as many medicinal mushrooms can have a very mild effect on blood clotting.
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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