Can I take Paracetamol and Amoxicillin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known interaction between paracetamol and amoxicillin. It is safe to take these two medicines together.
In this article:
You can take paracetamol and amoxicillin together as they are processed by the body in different ways and do not interfere with each other's absorption, metabolism, or effectiveness.
Paracetamol is primarily broken down by the liver, while amoxicillin is mainly cleared through the kidneys.
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How to take paracetamol and amoxicillin together
Always follow the dosage instructions on the packet or those provided by your doctor or pharmacist.
If you are taking amoxicillin for an infection, make sure you finish the entire course even if you start to feel better.
Important precautions
Back to contentsLiver disease
You must not exceed the maximum dose of 4g (eight 500mg tablets) in 24 hours. Taking even a small amount more than the recommended dose can cause serious, permanent liver damage. Check all other medicines (like cold and flu remedies) to ensure they do not also contain paracetamol.
Penicillin allergy
Do not take this medicine if you have ever had an allergic reaction to penicillin or cephalosporin antibiotics. A reaction can be life-threatening.
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Food and drink warnings
Back to contentsAlcohol
While a small amount of alcohol is generally considered safe, you should avoid drinking large amounts of alcohol (heavy drinking) while taking paracetamol. Chronic heavy drinking increases the risk of serious liver damage if you take paracetamol, even at recommended doses.
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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