Can I take Sertraline and Citalopram together?

It is generally not recommended that you take sertraline and citalopram together as they are the same class of SSRI (antidepressant) and work in the same way to increase serotonin levels.

Taking them together creates an 'additive effect' where the levels become dangerously high, increasing the risk of serotonin syndrome. Additionally, both drugs can affect the electrical activity of the heart in a similar way.

You should not take these two medicines together unless specifically instructed and closely monitored by a specialist.

How to know if you're having a drug interaction

You may be experiencing a drug interaction between sertraline and citalopram if you notice:

• Agitation, restlessness or confusion.

• Shivering or sweating.

• Muscle twitching, stiffness or jerking movements.

• Fast heartbeat.

• Diarrhoea.

• Headache.

• Feeling unusually anxious or overactive.

These may be signs of serotonin syndrome, which can be serious.

Seek urgent medical help if you have:

• A high fever.

• Severe confusion or agitation.

• Seizures.

• Irregular heartbeat.

• Loss of consciousness.

If you are currently taking both, do not stop taking them suddenly, but contact your doctor immediately to discuss a safe plan.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.