Can I take Simvastatin and Venlafaxine krka together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together may slightly increase the level of simvastatin in your blood. This can increase the risk of side effects, particularly muscle pain or weakness.
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Why this happens
Both medicines are processed by the same enzyme in the liver (CYP34A). Because they are 'competing' for the same enzyme, the body may break down simvastatin more slowly than usual.
What you should do
Back to contentsYou can usually take these together, but you should be vigilant. Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. Your doctor may choose to monitor your liver function or adjust your dose if you experience side effects.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
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Taking atorvastatin and prednisolone together may increase the risk of muscle-related side effects, such as muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis, where muscle tissue breaks down and can cause kidney damage. Additionally, prednisolone can raise blood sugar levels, which may slightly reduce the effectiveness of atorvastatin in managing your cholesterol profile.
Treatment and medication
Can I take Omeprazole and Ibuprofen together?
Taking these two medicines together is generally safe and is often done intentionally. Omeprazole can actually help protect your stomach from the irritation or ulcers that ibuprofen can sometimes cause. However, there is a very small chance that omeprazole might slightly reduce how quickly or effectively the ibuprofen works for pain relief, though most people do not notice this.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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