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Can I take Tramadol and Venlafaxine together?

Drug interaction guide

Originally published 25 Jan 2026

Meets Patient’s editorial guidelines

Taking these two medicines together significantly increases the risk of a rare but serious condition called 'serotonin syndrome'. This occurs when there is too much of a chemical called serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle twitching, or diarrhoea. In rare cases, this combination can also increase the risk of having a seizure (a fit).

In this article:

It is not recommended that you take tramadol and venlafaxine together as both medicines increase the levels of serotonin in the brain, which can raise the risk of a serious reaction called serotonin syndrome.

Additionally, both drugs can lower the 'seizure threshold', making it easier for the brain to experience a seizure.

Continue reading below

How to know if you're having a drug interaction

You may be experiencing a drug interaction between tramadol and venlafaxine if you notice:

  • Agitation, restlessness or confusion.

  • Shivering or sweating.

  • Muscle twitching, stiffness or jerking movements.

  • Fast heartbeat.

  • Diarrhoea.

  • Headache.

  • Feeling unusually anxious or overactive.

These may be signs of serotonin syndrome, which can be serious.

Seek urgent medical help if you have:

  • A high fever.

  • Severe confusion or agitation.

  • Seizures.

  • Irregular heartbeat.

  • Loss of consciousness.

Using other medicines

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Taking these two medicines together significantly increases the risk of a rare but serious condition called 'serotonin syndrome'. This happens when there is too much of a chemical called serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle twitching, or diarrhoea. In severe cases, it can be life-threatening.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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