Can I take Amoxicillin and Clarithromycin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no harmful interaction between amoxicillin and clarithromycin. In fact, these two antibiotics are very commonly prescribed together to treat certain types of infections, such as stomach ulcers caused by H. pylori bacteria or severe pneumonia.
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Why this happens
Amoxicillin (a penicillin) and clarithromycin (a macrolide) work in different ways to kill bacteria. Amoxicillin attacks the bacterial cell wall, while clarithromycin stops the bacteria from making proteins. Because they attack the infection from two different angles, they can be more effective when used together.
What you should do
Back to contentsIt is safe to take these medicines together as prescribed by your doctor. Ensure you finish the full course of both antibiotics, even if you start to feel better. If you experience severe diarrhoea or a skin rash, contact your doctor.
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Important precautions
Back to contentsHeart rhythm disorders (Long QT syndrome)
Clarithromycin can cause serious heart rhythm problems. You must not take it if you have a history of 'Long QT syndrome' or are taking other medicines that affect your heart rate.
Severe diarrhoea (C. diff)
If you develop severe, watery, or bloody diarrhoea during or after treatment, stop taking the medicines and contact your doctor immediately. This can be a sign of a serious bowel inflammation.
Statin medication (e.g., simvastatin, atorvastatin)
Do not take clarithromycin if you are taking simvastatin or lovastatin. Taking them together can cause severe muscle breakdown (rhabdomyolysis). Consult your pharmacist if you take any other statins.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice can increase the levels of clarithromycin in your blood, which may increase the risk of side effects. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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