Can I take Aspirin and Omeprazole together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together is generally safe and often beneficial. Omeprazole can actually help protect your stomach from the irritation or ulcers that aspirin sometimes causes. However, omeprazole might slightly change how quickly or how well your body absorbs certain types of aspirin (like enteric-coated tablets).
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Why this happens
Omeprazole reduces the amount of acid in your stomach. Some aspirin tablets have a special coating (enteric coating) designed to dissolve only when they reach the gut. By making the stomach less acidic, omeprazole might cause this coating to break down too early in the stomach, or it may slightly alter how the aspirin is absorbed into the bloodstream. Despite this, the overall effect of the aspirin is usually not changed enough to be a concern.
What you should do
Back to contentsYou can take these medicines together. In fact, doctors often prescribe them together specifically to protect the stomach lining if you need to take aspirin long-term. If you are taking aspirin to prevent heart problems or strokes, continue to take it as prescribed. If you notice any unusual stomach pain or indigestion, mention it to your pharmacist or doctor.
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Important precautions
Back to contentsAsthma
Do not take aspirin if you have a history of asthma triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can cause a severe, life-threatening allergic reaction or asthma attack.
Pregnancy (third trimester)
Do not take aspirin during the last 3 months of pregnancy unless specifically prescribed by a specialist, as it can cause serious heart and kidney problems in the unborn baby and increase the risk of bleeding during delivery.
Severe diarrhoea
Contact your doctor immediately if you develop severe or persistent watery diarrhoea; omeprazole can increase your risk of a serious bowel infection caused by Clostridium difficile.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking aspirin can increase the risk of irritation and bleeding in your stomach. It is best to limit alcohol intake or avoid it if you have a history of stomach issues.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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