Can I take Covosevalam and Naproxen bp together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking colesevelam (Covosevalam) at the same time as naproxen can significantly reduce the amount of naproxen your body absorbs. This means the naproxen may not work as well to relieve your pain or inflammation.
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Why this happens
Colesevelam is a 'bile acid sequestrant' designed to bind to substances in your digestive system. It can accidentally trap naproxen molecules, preventing them from entering your bloodstream.
What you should do
Back to contentsYou should separate the doses of these two medicines. Take your naproxen at least 1 hour before or 4 hours after you take your colesevelam. This gives the naproxen enough time to be absorbed by your body.
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Important precautions
Back to contentsAsthma
Do not take this medicine if you have asthma or a history of wheezing triggered by aspirin or other anti-inflammatory drugs, as it can cause a life-threatening asthma attack.
Stomach ulcers or bleeding
This medicine significantly increases the risk of stomach ulcers and internal bleeding. Seek immediate medical help if you pass black, tarry stools or vomit blood.
Bowel obstruction or high triglycerides
Do not take this if you have a history of bowel obstruction or very high triglyceride levels, as it can cause severe constipation or trigger acute pancreatitis.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking naproxen can increase the risk of stomach irritation and serious side effects like stomach ulcers or bleeding. It is best to limit or avoid alcohol while on this medication.
Fat-soluble vitamins (A, D, E, K)
Colesevelam can interfere with the absorption of fat-soluble vitamins from your food. It is often recommended to take this medicine with a meal to help it work, but you should monitor for signs of vitamin deficiency if taking it long-term.
Food (General)
You should take naproxen with or just after a meal or a snack. This helps to protect your stomach lining and reduces the risk of indigestion or stomach pain.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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