Can I take Metformin and Mitrazapine together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking mirtazapine alongside metformin may occasionally affect your blood sugar levels. While mirtazapine is generally considered 'weight-neutral' compared to other antidepressants, it can sometimes cause an increase in appetite or weight gain, which might make it slightly harder for metformin to control your blood sugar. There is also a very small risk that mirtazapine could interfere with how your body processes sugar, potentially leading to higher blood glucose levels.
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Why this happens
Mirtazapine can sometimes cause metabolic changes, such as increased appetite or changes in how the body responds to insulin. This can work against the blood-sugar-lowering effects of metformin.
What you should do
Back to contentsYou can usually take these two medicines together, but you should monitor your blood sugar levels more closely when you first start mirtazapine or if your dose changes. If you notice your blood sugar readings are consistently higher than usual, or if you feel unusually thirsty or tired, speak to your GP. They may need to adjust your metformin dose or give you advice on managing your weight.
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Important precautions
Back to contentsLactic acidosis risk
If you experience severe vomiting, diarrhoea, or dehydration, stop taking metformin and seek medical help immediately. This prevents a rare but serious build-up of acid in the blood, especially if you have kidney problems.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking metformin can increase the risk of a rare but serious condition called lactic acidosis. It can also cause your blood sugar levels to drop too low (hypoglycaemia). Avoid excessive drinking and binge drinking.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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